[HTML][HTML] 1α, 25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells
ZC Ryan, TA Craig, CD Folmes, X Wang… - Journal of Biological …, 2016 - ASBMB
Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal
failure, where concentrations of the active vitamin D 3 metabolite, 1α, 25-dihydroxyvitamin D
3 (1α, 25 (OH) 2 D 3), are low. To evaluate the mechanism of action of 1α, 25 (OH) 2 D 3 in
skeletal muscle, we examined mitochondrial oxygen consumption, dynamics, and
biogenesis and changes in expression of nuclear genes encoding mitochondrial proteins in
human skeletal muscle cells following treatment with 1α, 25 (OH) 2 D 3. The mitochondrial …
failure, where concentrations of the active vitamin D 3 metabolite, 1α, 25-dihydroxyvitamin D
3 (1α, 25 (OH) 2 D 3), are low. To evaluate the mechanism of action of 1α, 25 (OH) 2 D 3 in
skeletal muscle, we examined mitochondrial oxygen consumption, dynamics, and
biogenesis and changes in expression of nuclear genes encoding mitochondrial proteins in
human skeletal muscle cells following treatment with 1α, 25 (OH) 2 D 3. The mitochondrial …
